Zannis Vassilis

Zannis Vassilis

Vassilis I. Zannis received his Ph.D. in biochemistry from UC Berkeley, USA.

He is presently Professor of Medicine/Biochemistry and Director of Molecular Genetics at Boston University School of Medicine.

His research interests include apolipoprotein gene regulation in vivo, the role of apoA-I and apoE in lipid homeostasis and  the biogenesis of HDL, and the role of apoE in Alzheimer's disease.

Graduate Education

Degree             Discipline         University         Year of Award

PhD                Biochemistry       UC Berkeley            1975

Postdoctoral Training
1975-1977     Dept. of Medicine, University of California, San Francisco

1977-1978     Dept. of Chemistry, MIT, Cambridge

1978-1979     Metabolism Div., Children's Hosp. & Dept. Pediatrics, Harvard Medical School, Boston

Academic Appointments
1979-1982     Research Associate, Metabolism Div. & Dept. Pediatrics, Harvard Medical School, Fellow of The Medical Foundation, Inc., Boston

1982-1984     Assistant Professor, Pediatrics-Biochem., Dept. Pediatrics, Harvard Med. Sch., Boston

1984-1987     Assoc. Prof. Medicine/Biochem­istry, BUSM, Director, Molecular Genetics,

1986-pres       Professor of Biochemistry, Univ. of Crete Medical School, Crete, Greece

1987-pres       Prof. Medicine/Biochemis­try, BU School of Medicine, Director, Molecular Genetics,

Hospital Appointments
Children’s Hospital Medical Center, Boston

Major Awards and Honors
1983-1986     Established Investigator Award of the American Heart Association

Major Memberships, Offices and Committee Assignments in Professional Societies
1981, American Chemical Society; 1981, Fellow, Council on Arteriosclerosis, American Heart Association; 1983, American Society of Biological Chemistry and Molecular Biology; 1997, American Society of Gene Therapy; 1999, European Atherosclerosis Society; 1999, Hellenic Society of Lipidiology and Atherosclerosis (President, 2004-2006)

Editorial Boards
2000-2002     Current Opinion in Lipidology

Evaluation of International Research Projects
1985-2003, NIH ad hoc Committee Member; 1986/1987, EPET; 1993/1998, European Union grants; 1999-2004, American Heart Association

Invitations to International Meetings and Conferences
Participant on an average of 3 meetings per year.

General Research Area
Molecular genetics of apolipoproteins and lipoproteins in relation to atherosclerosis and Alzheimer’s disease

Research  Interest and Ongoing Research:

  • Elucidation of the structure-functions of human apoA-I and apoE in vivo using transgenic and gene transfer methodologies. Role of apoA-I in the biogenesis and the functions of HDL. Role of apoE in cholesterol and triglyceride homeostasis in the circulation. Role of apoE in lipid homeostasis in the brain, and the pathogenesis of Alzheimer's disease.

Transcriptional regulation of the apoA-I, apoCIII and apoA-IV gene cluster in vivo using antisense and transgenic methodologies and adenovirus-mediated gene transfer.  

Research Publications

       Total number of original articles in peer-reviewed journals: 160

       Total number of reviews and book chapters: 47

       Total number of citations: ~6,000

       Average Impact Factor: ~6